Research progress on the mechanism of hemorrhagic transformation caused by tPA thrombolysis and the intervention effect of small molecule compounds
HUANG Juan
ZHANG Miling
YU Junhe
GONG Shuaishuai
KOU Junping
Abstract：Tissue type plasmin activator(tPA)is the only drug approved by the US Food and Drug Administration for the treatment of acute ischemic stroke.However,its clinical application is limited due to the narrow treatment time window and severe hemorrhagic transformation(HT).In this paper,the mechanism of HT development was reviewed from the per-spectives of blood-brain barrier disruption,neuroinflammation,oxidative stress,and nitrite stress,as well as the research progress of small molecule compounds on HT protection published in domestic and foreign journals in the past seven years.This information would provide some clues and references for the new drug development and drug combination for the ische-mic stroke.
Keywords：Tissue plasmin activatorHemorrhagic transformationSmall molecule compoundsResearch progress
Publication Date：2024-04-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 384-390,401 )