The role of cell death in sepsis-induced kidney injury
ZHOU Wenchen
HE Chaoyong
Abstract：Sepsis is a systemic inflammatory response syndrome caused by infection,accompanied by acute injury to multiple organs.Sepsis-induced acute kidney injury(AKI)is one of the most severe complications and may turn into chronic kidney disease(CKD).The pathophysiology involves a variety of cells,including renal vascular endothelial cells,tubular epi-thelial cells and macrophages.The associations between these cells and cell death are strongly associated with kidney injury induced by sepsis.Endoplasmic reticulum stress,mitochondrial dynamic imbalance and oxidative stress are the main causes of cell death.
Keywords：SepsisKidney injuryCell death
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 60-66 )