Toxicity study on single and repeated dose of Ultrafine Granular Powder of Houttuynia cordata Thunb
LEI Xialing
DENG Wen
CHEN Weixuan
DAI Jinlong
GUO Jianming
HUANG Yuankeng
ZHANG Qianliang
CHENG Jinle
YANG Wei
Abstract：Objective To study the toxicity of Ultrafine Granular Powder of Houttuynia cordata Thunb.after single and repeated dose in rats,and to provide reference basis for clinical research and application.Methods Both Ultrafine Granular Powder of Houttuynia cordata Thunb.and Houttuynia Decoction Pieces were given by single gavage with the maximum dose of 7.2 g·kg-1,and the toxic reactions were observed for 2 weeks;SD rats were given 3-month gavage administration of Ultra-fine Granular Powder of Houttuynia cordata Thunb.with 1.35,2.70 and 5.40 g·kg-1,and Houttuynia Decoction pieces of 1.35 and 5.40 g·kg-1,with 4 weeks recovery period respectively.Clinical observation,body weight,food intake,blood biochem-istry,hematology,renal injury biomarkers,and pathology were performed.Results Ultrafine Granular Powder of Houttuynia cordata Thunb.and Houttuynia Decoction Pieces were administered orally in SD rats at a single dose of 7.2 g·kg-1,and no obvious toxicity was observed.Moreover,Ultrafine Granular Powder of Houttuynia cordata Thunb.and Houttuynia Decoction Pieces were repeatedly administered for 3 months,and no abnormality was found in each dose group.Conclusion The max-imum tolerable dose(MTD)of single oral administration of Ultrafine Granular Powder of Houttuynia cordata Thunb.and Houttuynia Decoction Pieces in SD rats was more than 7.2 g·kg-1.The no observed adverse effect level(NOAEL)dose of Ul-trafine Granular Powder of Houttuynia cordata Thunb.and Houttuynia Decoction Piece in SD rats by gavage administration for 3 months was 6.4 g·kg-1.Thus,at the same dose,there was no significant difference between Ultrafine Granular Powder of Houttuynia cordata Thunb.and Houttuynia Decoction Piece in SD rats.
Keywords：Ultrafine Granular Powder of Houttuynia cordata Thunb.Houttuynia Decoction PieceSingle dose toxicity studyRepeat dose toxicity studyNephrotoxicity
Publication Date：2024-01-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 19-23,34 )