Research progress in the mechanism of action of small molecular compounds on PKM2
YU Huailong
YU Jiaying
ZHANG Jinghong
Abstract：Pyruvate kinase M2(PKM2) may play an important role in regulating the glucolysis,proliferation and signal transduction of tumor cells.The constantly deepened researches in this field will endow the development of the new targets of anticancer drugs with bright prospect for the therapy of clinical.By the method of literature summary,the present paper,discusses the mechanism that the small molecule compounds modulate the expression regulation,inhibition and excitation of PKM2 and puts forward to be an important research direction in the anti-tumor drug screening.
Keywords：Pyruvate kinase M2The mechanism of actionSmall molecular compounds
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 347-352 )