Polymorphism of drugs:the main factor affecting the drug quality
DU Guanhua
LYU Yang
Abstract：The quality of the small molecule drugs is an important and complex problems which related to clinical therapeutic effects.There are many different factors influencing the quality of drugs include API,excipients and preparation technology related factors.Except these factors,the crystal form of API is the core factors which closely related with bioavailability of drugs.Appliation and controlling the Optimal Drug Crystal form (ODC) of API in solid pharmaceutical preparations are the key procedures for drug quality.This article discussed the discovery,detection,evaluation and application requirements of drug crystal,to provide information for the study of crystalline drugs.
Keywords：Chemical solid medicineCrystal formDrug qualityInfluencing factors
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 311-314,336 )