Design strategy of anti-androgen targeting the non-HBP sites of androgen receptor
LIU Yangguang
WU Meng
CEN Shan
ZHOU Jinming
Abstract：Androgen receptor (AR) is the most important target for the therapy of prostate cancer.However,the drug resistance during the treatment becomes the greatest challenge.Herein,we gave an overview of the structure and functions of AR and the drug resistances due to the mutations in the HBP site.Then this article summarized the design strategy of the AR antagonists targeting the non-HBP sites of AR,which should help to the development of novel anti-prostate cancer drugs.
Keywords：Androgen receptorAnti-prostate cancerAnti-androgenAF2BF3CRPC
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 249-254,258 )