Nanomaterial-induced autophagy:underlying mechanisms and functional consequences
HE Fufan
CHEN Huan
ZHANG Yubin
Abstract：Autophagy,a complex catabolic pathway,is bulk degradation of cytoplasmic components through the lysosome,which provides a highly dynamic quality control mechanism to maintain cellular homeostasis,and is also a protective mechanism in response to stress.A growing body of research suggests that autophagy is also activated upon internalization of engineered nanomaterials,most likely as a protective response to what is perceived as foreign or toxic.While activation of autophagy by nanomaterials can lead to enhanced clearance,it may also be associated with activation of cell death programs.This review described the mechanisms of autophagy activation in response to naturally occurring and engineered nanomaterials and provide a comprehensive analysis of the impact of nanomaterials on the lysosome-autophagy system and their functional consequences.
Keywords：AutophagyLysosomesNanomaterialsAutophagy-modulating effect
Publication Date：2017-04-02
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 226-230 )