Preparation of hollow gold nanoparticles by silver template method and its quality evaluation
YOU Chen
LI Lin
YANG Wenqian
SHEN Yan
TU Jiasheng
Abstract：Objective To prepare and characterize a hollow gold nanoparticles for loading drugs.Methods Preparing silver nanoparticles as templates,chloroauric acid was reacted with silver nanoparticles to produce gold shells by template-engaged replacement reactions.Then gold wrapped on the surface of silver nanoparticles,and finally formed a kind of hollow structure.The study on the preparation of hollow gold nanoparticles was carried out by single factor investigation.The structure of hollow gold nanoparticles was observed by transmission electron microscopy,and the absorption by UV scanning was investigated.Photothermal transformation of the carrier was researched by in vitro photothermal transformation experiment.And MTT assay was used to investigate the cytotoxicity of the vector.Results The hollow gold nanoparticles had a particle size of 35~55 nm with a shell thickness of 4~6 nm.The maximum absorption wavelength was 750~800 nm.And the preparation had good photothermal conversion ability.Cytotoxicity study in vitro indicated that the hollow gold nanoparticles did not cause significant toxicities on the HDF cells.Conclusion The optimized hollow gold nanoparticles had better hollow structure,good photothermal conversion ability and smaller cototoxicity.
Keywords：Hollow gold nanoparticlesSilver templatePhotothermal conversionCell toxicity
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 209-214 )