An overview in research and development process of a novel γ-secretase modulator SPI-1865
L(U) Xue
HU Lihong
Abstract：Alzheimer's disease is a progressive neurodegenerative disorder,which is lack of efficient treatment measures.The β-amyloid (Aβ) oligomers and senile plaques,which are the result of β-amyloid aggregation outside the brain neurons,are strongly implicated the pathogenesis of AD.γ-secretase,a key enzyme involved in generation of Aβ,is a potential target in the development of drugs for AD therapy.γ-secretase modulators(GSM) are highly selective and have broad application prospects.This article briefly reviewed the development process of a novel γ-secretase modulator SPI-1865,aiming at providing valuable information for development and structural modifications of related GSM.
Keywords：Alzheimer's diseaseβ-amyloidγ-secretaseγ-Secretase modulatorsSPI-1865
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 187-194 )