Application of Q-Exactive high resolution mass spectrometry to analysis of the Polymer in Cefoperazone Sodium and Sulbactam Sodium for Injection
YU Mingyan
LI Yujie
LING Xiao
Abstract：Objective To establish a Q-Exactive high resolution mass spectrometry(HRMS) method for the analysis of the polymer and impurities in Cefoperazone Sodium and Sulbactam Sodium for Injection.Methods The HPLC was performed on a TSK GEL 2000SWXL column(7.8 mm×30 cm,5 μm)with 0.1% Formic acid-acetonitrile(97∶3) as mobile phase.Data was collected under positive/negative ion modes with ESI as ion resource.Results The method analyzed the polymer and impurities in Cefoperazone Sodium and Sulbactam Sodium for Injection based on analysis the feature fragmentation from Q-Exactive.Conclusion This paper established a new method for quality control of the polymer and impurities in Cefoperazone Sodium and Sulbactam Sodium for Injection,and thus provided reference to its quality control and process optimization.
Keywords：PolymerHRMSSafety monitoring
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 145-148,152 )