Application of sodium alginate in Metformin Hydrochloride Sustained-release Tablets
WANG Fuzhou
WANG Zhonghua
HAO Guanhua
Abstract：Objective To prepare Metformin Hydrochloride Sustained - release Tablets with sodium alginate as sustained-release materials.Methods To compare the dissolution profile and stability between domestic and the brand drug with sodium alginate as sustained-release material in Metformin Hydrochloride Sustained-release Tablets.Results Similar-ity factors(f2 )of several critical pH dissolution medium between domestic and the brand drug was more than 70,and the related substances of domestic are no significant increase,the average tablet weight of domestic was 850 mg,while the brand drug was 1 000 mg.Conclusion With sodium alginate as sustained-release materials,Metformin Hydrochloride Sustained-release Tablets had the same dissolution profile as the brand drug.The formulation and process of Metformin Hydrochloride Sustained-release Tablets with sodium alginate as sustained-release materials were reasonable and practicable,its process was stable and the quality was controlled.
Keywords：Sodium alginateSustained release materialsDissolution profile in vitroStability
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 653-656 )