Determination of ibuprofen sodium by HPLC and potentiometry titration
HONG Sangsang
WANG Haixiang
WANG Suilou
Abstract：Objective To establish a potentiometry titration method and an HPLC method for the determination of ibu-profen sodium.Methods The HPLC method was performed on a C18 column(4.6 mm×250 mm,5 μm)with mobile phase of 0.05% phosphate acid-acetonitrile(60: 40,V/ V)at flow rate of 2.0 mL·min-1 .The UV detection was set at 214 nm and the colum temperature was matained at 30 ℃ . Ethanol was used as solvent for potentiometry titration. The sample solution was titrated with 0.1 mol·L-1 hydrochloric acid solution.The end point was decided by potentiometric method.Re-sults HPLC:the liner range for ibuprofen sodium was 0.08~0.32 mg·mL-1(r= 0.999 8),the precision RSD was 0.41%(n= 6),the average recovery was 99. 4% with an RSD of 0. 90%( n = 9). Potentiometry titration:the liner range for ibuprofen sodium was 0.18~0.42 g(r= 1.000 0),the precision RSD was 0.14%(n= 6),the average recovery was 100.2%with an RSD of 0. 13%(n= 9).Conclusion There was no significant difference between the results of potentiometry titra-tion method and HPLC method and indicated that two methods both could be used to determine the content of ibuprofen so-dium substances.
Keywords：HPLCPotentiometry titration methodIbuprofen sodiumDetermination
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 642-645 )