An overview of structural modifications of amphotericin B
LYU Xue
HU Lihong
Abstract：Amphotericin B has been the first choice of clinical drugs to treat systemic mycosis since it was launched on the market,which makes full use of its curative effects by selectively disrupting the cell membrane of fungi.But its clin-ical applications are greatly limited due to several drawbacks,such as poor solubility,low bioavailability,severe side effects,etc.Many scientists have devoted themselves to explore the mechanism of action and structural modification of am-photericin B over the years,and achieved significant results.This article briefly reviewed the progress in structural modifi-cation of amphotericin B,aiming at providing valuable information for related research.
Keywords：Amphotericin BStructural modificationDerivativesMechanism of action
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 621-627 )