Effects of Mudan Particles combined with irbesartan on the levels of serum transforming growth factor-β1 and homocysteine in patients with early diabetic nephropathy:A randomized,open,parallel,controlled study
LI Weihua
DI Huifeng
CHEN Yingying
WANG Debao
LIU Peng
Abstract：Objective To investigate the effects of Mudan Particles combined with irbesartan on the levels of serum transforming growth factor-β1(TGF-β1)and homocysteine(Hcy)in patients with early diabetic nephropathy.Methods Application of prospectively randomized,open,parallel,controlled methods,a total of 72 patients with early diabetic ne-phropathy were selected,and were randomly divided into two groups for Mudan Particles combined with irbesartan (combined therapy)or irbesartan treatment,respectively.Changes in urinary albumin excretion rate(UAER),urine β2-mi-croglobulin(β2-MG),the levels of serum TGF-β1 and Hcy were measured and compared between two groups at both pre-and post-treatment of 48 weeks.Results There were no statistically significant difference in the baseline clinical character-istics of study participants between two treatment groups( P﹥0. 05 ). Comparison of therapy-related differences between groups showed that the combined therapy was better in reducing UAER,urineβ2-MG and serum TGF-β1 than the irbesar-tan group[(-37±12 vs -22±10)μg·min-1,(-0.40±0.17 vs -0.24±0.12)mg·L-1,(-31±15 vs -14±12)U·L-1,re-spectively,all P﹤0.01].Conclusion Compared with irbesartan monotherapy,Mudan Particles combined with irbesartan treatment can better reduce serum TGF-β1 levels,decrease UAER and urine β2-MG,and may exert kidney protection effects in patients with early diabetic nephropathy.
Keywords：Mudan ParticlesDiabetic nephropathyTransforming growth factor-β1Homocysteine
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 545-547,558 )