Synthesis and anti-tumor activity of ursolic acid derivatives
MENG Yanqiu
LI Sizhu
Abstract：Objective To study the inhibitory ability of pentacyclic triterpenoids novel compounds to cancer cells,and thus find new anticancer drugs.Methods Structure of natural product-ursolic acid was modified for increasing its antitumor activity.Eight new derivatives of ursolic acid were designed and synthesized by the structure modified at C-2 hydrogen,C-3 hydroxyl group,C-28 carboxy group and ring A. Results The antitumor activities of target compounds were evaluated by MTT assay.The results indicated that all the compounds had a degree of inhibition on cell proliferation of HeLa,HepG2 and BGC-823 cells.Compound I3 showed strong inhibitory activity to HeLa,HepG2 and BGC-823 cells.Conclusion The com-pounds showed strong inhibitory activity on these three kinds of tumor cells,significantly higher than the listed drug Ge-fitinib,and were worth to be intensively studied further.
Keywords：Ursolic acid derivativesAntitumor activityInhibitor
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 514-516 )