Synthesis and antitumor activity evaluation of the derivatives of 1,2,4 - triazole -5 - thione bis - schiff base
LI Min
ZHANG Yuna
TIAN Yushun
Abstract：Objective To design and synthesize a series of new derivatives of 1,2,4 - triazole - 5 - thione bis - schiff base and detect their antitumor activities in vitro. Methods the target molecules(7a ~ 7g)were synthesized by a series of reaction. The structures were characterized by 1 H - NMR and IR,and the growth inhibitory activities in vitro were evaluated by MTT assay against HeLa,HCT116 and BEL - 7402 cells. Results Compared with the positive control DDP,compound 7a,7b,7d,7e and 7g expressed significant stronger anti - proliferation effects against HCT116 cells,and 7a and 7d showed obvious inhibitory activities against HeLa cells,and BEL - 7402 cells,7d displayed the most significant inhibitory activity. Conclusion Compound 7d expressed significant anti - tumor activities in vitro against the three kinds cancer cells. Howev-er,the other compounds showed different inhibitory activities against tumor cell lines obtained from different tissues.
Keywords：124 - triazole - 5 - thione derivativesSchiff baseAntitumor activityMTT assayCisplatin
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 376-378,389 )