Study on dissolution of Mitiglinide Calcium Hydrate Tablets
ZHANG Xiaoli
LING Yiping
LUO Yaqin
XU Shaojing
Abstract：Objective To establish a dissolution determination method of Mitiglinide Calcium Hydrate Tablets and compare the self -made sample with the original preparation by stripping curves in four different dissolution media.Meth-ods The dissolution was determined with paddle method (75 rpm)in 900 mL water and detected by HPLC.Results There was a good linearity over the range of 2.775 ~33.300 μg·mL -1 with a correlation coefficient r =0.999 9,and aver-age recovery was 99.38%.Dissolution behaviors of self -made sample and original preparation are similar in four different dissolution media.Conclusion The method was simple,accurate,reliable and the quality of Mitiglinide Calcium Hydrate Tablets can be well controlled by this method.The dissolution behaviors of two samples were very similar in vitro.
Keywords：Mitiglinide calcium hydrateTabletsDissolutionHPLCStripping curve
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 347-350 )