Comparative study of the stripping curve of Sanhuang Xiexin Compound Granules and single herb formula granules in four mediums
SONG Ning
BAI Jun
LI Yang
LI Xinguang
CHENXin
Abstract：Objective To compare the dissolutions of Sanhuang Xiexin Compound Granules and single herb formula granules in four common difference of dissolution medium.Methods Using sirup method,water,artificial gastric juice with pH 1 .2,acetate buffer with pH 4.0,phosphate buffer with pH 6.8 for each 500 mL as dissolutions mediums,the dissolution of two granules were determined by HPLC,and stripping curves was obtained and to compare the differences.Results Arti-ficial gastric juice with pH 1 .2 was the best dissolution medium.The dissolution of Sanhuang Xiexin Compound Granules was higher than single herb formula granules.Conclusion The dissolutions of two granules in four different medium were differences.The dissolution of Sanhuang Xiexin Compound Granules prepared by boiling process was more complete.In the future,the dissolution problems of single herb formula granules should be paid attention in clinical application.
Keywords：Boiling processSanhuang Xiexin Compound GranulesDissolution
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 341-343,369 )