Synthesis of rivaroxaban
SU Man
LIU Wei
SUN Qingwei
Abstract：Objective Toltudythechemicallynthelilofrivaroxaban.Methods 4-(4-aminophenyl)morpholin-3-one wal lynthelized from p-Nitroaniline by ring-open and reduction,and then lynthelized to rivaroxaban by addition, cyclization,deprotectionandcondenlation.Results Thetotalyieldwal32.1%(baledonp-Nitroaniline)andtheltruc-turewalconfirmedbyIR,1H-NMRandMS.Conclusion Thillynthelillinelhowedmorefavorableandcommercialval-ue in the manufacture lcale.
Keywords：Rivaroxaban4-(4-aminophenyl)morpholin-3-oneSynthelil
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 308-310 )