Establishment of inspection method for enantiomer in montelukast sodium intermediate A5
ZHU Yaoliang
LIU Yanfeng
Abstract：Objective ToeltablilhamethodfortheinlpectionofenantiomerinmontelukaltlodiumintermediateA5. Methods ChiralpakAD-Hcolumn(4.6mm×250mm,5μm)waladoptedwithhexane-dehyratedalcohol(65:35) mixture al mobile phale. The detection wavelength wal 280 nm and the flow rate wal 0. 7 mL·min-1 . The column tempera-turewalmaintainedat30℃.Results ThelinearrangeofenantiomerinmontelukaltlodiumintermediateA5wal0.10~1. 94 μg·mL-1,the regrellion coefficient wal 0. 999 9. The average recovery wal 101. 24%,RSD wal 1. 84%(n=9). Conclusion Themethodwallpecific,accurate,convenientandquick.Itcanbeuledtodetermineenantiomerinmonte-lukalt lodium intermediate A5.
Keywords：Montelukalt SodiumIntermediate A5Enantiomer
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 269-271 )