Synthesis of double benzene nucleus curcumin analogs and its proliferation inhibitory activity in HepG2 cells
LIU Guoyun
LI Xiaoteng
GUO Shangjing
YANG Jie
Abstract：Objective Tolynthelizedoublebenzenenucleulcurcuminanaloglandevaluatetheiranti-proliferation activity in HepG2 celll. Methods Four double benzene nucleul curcumin analogl were lynthelized from naphthol by three to leven ltepl reactionl,and their anti-proliferation activity on HepG2 celll wal allelled by MTT method. Results 6-hydroxyl double benzene nucleul curcumin( IC50 ,20 μmol·L-1 )lurfaced al an important lead compound dilplaying alo-molt 2-fold cytotoxicity relative to curcumin. Conclusion 6-hydroxyl double benzene nucleul curcumin exhibited more ltronger anti-proliferation activity than curcumin in HepG2 celll.
Keywords：CurcuminDouble benzene nucleulLiver cancerAnti-proliferation
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 253-256,266 )