Influence of compatibility on tissue distribution of ephedra alkaloids of the drug pairs of Herba Ephedrae and Radix Glycyrrhizae in rats
WEI Ping
MA Qinhai
REN Mengyue
LUO Jiabo
Abstract：Objective To investigate the tissue distribution characteristics of ephedra alkaloids in SD rats before and after the compatibility of Herba Ephedrae and Radix Glycyrrhizae,and to reveal the tissue distribution difference of ephedra alkaloids effected by Radix Glycyrrhizae based on the drug interaction. Methods The concentration of ephedra alkaloids in tissues of rats in different time before and after the compatibility of Herba Ephedrae and Radix Glycyrrhizae were determined by UPLC - MS/ MS method,to compare the difference of distribution of ephedra alkaloids under the two administration mod-els. Results Compared with the Herba Ephedrae group,after the compatibility of Radix Glycyrrhizae,it promoted the ab-sorption and distribution of norephedrine,ephedrine and pseudoephedrine in research tissues;It accelerated the eliminate of norephedrine,ephedrine,pseudoephedrine and methylephedrine from brain;It inhibited the absorption and distribution of norpseudoephedrine in brain and heart,and accelerated its elimination from brain and heart,and the elimination of norephedrine from heart,lung and kidney,the elimination of ephedrine from heart and the methylephedrine from lung and kidney. Conclusion There had a significant impact on the tissue distribution of ephedra alkaloids in rats because of the compatibility of Herba Ephedrae and Radix Glycyrrhizae.
Keywords：Herba EphedraeRadix GlycyrrhizaeEphedra alkaloidsUPLC - MS/ MSCompatibilityTissue distribution
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 187-192 )