Intestine absorption study on riboflavin with rat single pass intestinal perfusion technique
WANG Lifeng
GUO Daliang
HUANG Fuqiang
LI Tao
Abstract：Objective To study the absorption of riboflavin in rat intestine.Methods The absorption of riboflavin in the small intestine (duodenum,jejunum and ileum)of rat was investigated using the gravimetry of the rat single pass intes-tinal perfusion technique.The drug concentration was measured by HPLC to acquire drug Pef and Ka .Results The Pef(× 10 -4 cm·s -1 )in duodenum,jejunum and ileum were 1.002 ±0.630,0.818 ±0.386,0.796 ±0.372.The Ka (×10 -3 s -1 )were 1.114 ±0.625,0.905 ±0.452,0.873 ±0.369.Conclusion The riboflavin could be absorbed in all the intesti-nal segments.The best part of intestine to absorb riboflavin was duodenum.
Keywords：RiboflavinIntestinal absorptionSingle pass intestinal perfusionEffective permeability
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 136-138,153 )