Chemical constituents from the stems of Clausena lansium
LIU Jie
LI Chuangjun
YANG Jingzhi
MA Jie
ZHANG Dongming
Abstract：Objective To study the chemical constituents from the stems of Clausena lansium (Lour.)Skeels.Meth-ods The chemical constituents were separated and purified by macroporous resin,MCI gel,silica gel,ODS column chroma-tography,Sephadex LH -20,and preparative HPLC,and their structures were determined by the analysis of ultraviolet spec-trum,mass spectrum,and nuclear magnetic resonance spectroscopy.Results Ten compounds were isolated from the H2 O fractions of 95% ethanol extract of the stems of Clausena lansium,and their structures were identified as β-Adenosine(1), Umbelliferone -7 -α-L -rhamnopyranosyl -(1″-6′)-β-D -glucopyranoside(2),Haploperoside A(3),Umbellifer-one -7 -O -β-D -rhamnopyranosyl -(1″-6′)-β-D -glucopyranoside(4),marmesinin(5),Benzyl -O -β-D -apiofuranosyl -(1″-6′)-β-D -glucopyranoside(6),Benzyl -O -β-D -glucopyranoside(7),3 -(4 -hydroxyphe-nyl)-propanoic acid(8),β-hydroxypropiovanillone (9),trans -p -hydroxycinnamic acid(10).Conclusion Com-pounds 1 ~6,8 ~9 were isolated from the plants of genus Clausena L.Compounds 1 showed some inhibitory effects on LPS-induced NO production in murine microglial BV2 cells (IC50 =4.39 μmoL·L -1 ).
Keywords：Clausena L.Clausena lansium(Lour.)SkeelsAdenosineUmbelliferone3 -(4 -hydroxyphenyl)-pro-panoic acid
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 125-128,184 )