Preparation of gypenoside self - microemulsifying drug delivery system
ZHONG Wan-hua
LIU Dan-xia
CUI Sheng-miao
Abstract：Objective To prepare gypenoside self - microemulsifying drug delivery system(SMEDDS)and evaluate its quality. Methods The optimized formulation of gypenoside SMEDDS was screened by solubility,ternary phase diagrams and central composite design - response surface method with the particle size,the Zeta potential and the time of self - emul-sification as parameters. The physic - chemical property and dissolution characters of gypenoside SMEDDS were also deter-mined. Results The optimized formulation was composed of tween - 80(52% ),glycerol(30% ),ethyl oleate(26% ). The average particle size after the emulsification was 51. 21 nm,the Zeta potential - 13. 7 mV,the time of self - emulsification was 30. 54 s. The percent of accumulated dissolution of gypenoside in SMEDDS in vitro was 5 times of crude material at 45 min. Conclusion The preparation method of gypenoside SMEDDS was feasible,which can significantly increase the disso-lution of gypenoside.
Keywords：GypenosideSelf - microemulsifying drug delivery systemTernary phase diagramCentral composite de-signResponse surface method
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 654-657,678 )