Effect of total flavone of Hawthorn leaf on p38 protein in brain of the chronic cerebral ischemia rats
LI Meng-meng
ZHAO Xing-long
YIN Mei-juan
ZHANG Qiang
WU Xiao-guang
ZHAO Shu-min
BAI Jiang-tao
Abstract：Objective To investigate the therapeutic effect and mechanism that total flavone of Hawthorn leaf(TFHL) on p38 protein in brain of the chronic cerebral ischemia rat. Methods Male healthy SD rats were randomly divided into sham group,model group,TFHL group and Ginkgo leaf group. Permanent bilateral carotid artery ligation was used to prepare chronic cerebral ischemia model. Morris water maze method was used to evaluate learning and memory abilities of rats;Western blot method was used to measure the expression of p38 protein(P < 0. 05). Results Compared with the model group,TFHL treatment can improve learning and memory capabilities of vascular dementia rats,shorten the escape latency (P < 0. 05),increase the number of crossing the platform(P < 0. 05)and dramatically inhibit the expression of p38 protein (P < 0. 05). Conclusion TFHL played a protective role to nerve function of the chronic cerebral ischemia rat. The mecha-nism of its anti - apoptosis might be associated with down - regulating expression of p38 protein,reduced the apoptosis of neuron in the brain.
Keywords：TFHLChronic cerebral ischemiaLearning and memoryp38 protein
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 628-630,647 )