Clinical study of Rosuvastatin combined with Alprostadil Injection in the treatment of diabetic nephropathy
JU Fu-xia
Abstract：Objective To observe the clinical efficacy of Rosuvastatin combined with Alprostadil Injection in the treat-ment of diabetic nephropathy. Methods Ninety patients were randomly divided into two groups:45 patients of alprostadil group were treated with Alprostadil Injection 20 μg,qd;45 patients in combination therapy group were treated with Rosuvas-tatin 10 mg,po,qd and Alprostadil Injection 20 μg,qd. All patients in each group received the correlative therapy for 24 weeks. The urinary albumin excretion rate(UAER),serum creatinine(Scr),blood lipid were observed and recorded before and after the treatment. Results After the treatment,UAER,24 h urine protein decreased in two groups(P ﹤ 0. 01). But the UAER,24 h urine protein decreased in combination therapy group which was better than those in alprostadil group(P ﹤0. 01). The Scr and fasting blood glucose decreased in two groups with no significant difference among them(P ﹥ 0. 05). The blood lipid was improved in two groups(P ﹤ 0. 01),especially in combination therapy group. Conclusion Rosuvastatin and Alprostadil Injection in combination therapy were superior to monotherapy in the treatment of diabetic nephropathy.
Keywords：Diabetic nephropathyRosuvastatinAlprostadil Injection
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 608-610 )