Determination of homopiperazine in Fasudil Hydrochloride Injection by ion chromatographic
SHEN Yan-li
LIU Jian-ping
Abstract：Objective To establish an ion chromatographic method for the determination of homopiperazine in Fasudil Hydrochloride Injection. Methods The samples were analyzed on the IonPac CS12A(4 mm × 250 mm)exchange column, and connected the external suppressor,the mobile phase was 20 mmol·L - 1 mesilate in water - acetonitrile(80:20),the re-gen liquid was 100 mmol·L - 1 tetrabutyl ammonium hydroxide in water,the flow rate was 1. 0 mL·min - 1 ,the injection volumn was 50 μL and the detector temperature was 30 ℃. Results The linear range of homopiperazine was 0. 30 ~ 7. 56μg·mL - 1 ,r = 0. 999 7,The average recovery was 99. 99%. Conclusion The established method was senstitive,specific, repeatable and suitable for the determination of homopiperazine in Fasudil Hydrochloride Injection.
Keywords：Ion chromatographicSuppressorFasudil Hydrochloride InjectionHomopiperazine
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 581-583 )