Preparation and dissolution of Regorafenib Solid Dispersion in vitro
LIU Zheng-ping
LIU Jun-tian
WANG Ming-sen
ZHANG Jian-qiang
ZHAO Guo-min
ZHENG De-qiang
Abstract：Objective To enhance the dissolution rate of regorafenib which is a poorly water - soluble drug by forma-tion of solid dispersion. Methods Solid dispersions of regorafenib were prepared by solvent method with polyvinylpyrroli-done K30 as a carrier. The dissolution of the solid dispersions in vitro was determined by UV spectrophotometry and the X- ray diffraction technology was used to analyse the distribution mode of regorafenib. Results The dissolution of rego-rafenib solid dispersions was much faster than that of regorafenib and the physical mixtures. The dissolution of regorafenib in vitro was increased as the increasement of the carrier proportion. Regorafenib existed as amorphous form in the carrier. Con-clusion Solid dispersion technology can significantly increase the dissolution of regorafenib in vitro.
Keywords：RegorafenibSolid dispersionDissolution
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 524-526,541 )