Determination of sulfamate and sulfate in Topiramate by ion chromatographic
LIU Jia-sheng
SUN Jian-he
Abstract：Objective To establish an ion chromatographic method for the determination of sulfamate and sulfate in Topiramate. Methods The samples were analyzed on the Hamilton PRP - X100 anion exchange column,connecting the suppressor. The mobile phase was methanol - 0. 8 g·L - 1 of phydroxybenzoic acid in water(2. 5∶97. 5)(adjust with sodium hydroxide solution to a pH of 10. 0 ± 0. 1). The regen liquid was 5 mmol·L - 1 sulfuric acid in water,the flow rate was 1. 5 mL·min - 1 ,the injection volumn was 100 μL and the detector temperature was 30 ℃ . Results The linear range of sulfa-mate(calculated on NH2 SO3 - )was 0. 61 ~ 6. 09 μg·mL - 1 ,r = 0. 999 3,the average recovery rate was 103. 22% . The lin-ear range of sulfate(calculated on SO4 2 - )was 0. 90 ~ 9. 02 μg·mL - 1 ,r = 0. 999 4,the average recovery was 103. 40% . Conclusion The method was senstitive,specific,repeatable and suitable for the determination of sulfamate and sulfate in Topiramate.
Keywords：Ion chromatographicSuppressorTopiramateSulfamateSulfate
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 519-520,552 )