Determination of etodolac in Etodolac Capsules by HPLC
WANG Zeng-ri
Abstract：Objective To establish an HPLC method for the determination of etodolac in Etodolac Capsules. Methods HPLC method was adopted with Diamonsil C18 column(4. 6 mm × 150 mm,5 μm). A mixture of acetonitrile:water +phosphoric acid[520:480(500 + 0. 25)]was used as the mobile phase. The flow rate was 1. 5 mL·min - 1 with the detec-tion wavelength at 274 nm. Results At the validated method,the excipient had no interference to the principal agent. A lin-ear range of etodolac was 24. 98 ~ 199. 8 μg·mL - 1(r = 0. 999 9). The average recovery was 99. 6% with RSD = 0. 47%(n = 9). Conclusion This method was simple,accurate,specific and could be used for the determination of etodolac in Etodolac Capsules.
Keywords：EtodolacHPLCDeterminationCapsule
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 451-452,471 )