Preparation of butyl ether - β - cyclodextrin and glibenclamide clathrate
LIU Kai
HE Yuan
Abstract：Objective To prepare butyl ether - β - cyclodextrin and glibenclamide clathrate,and explore their effect on improve the dissolution and stability of drug. Methods Phase solubility method was implemented to determine the ap-parent stability constant,neutralization was used to prepare butyl ether - β - cyclodextrin and glibenclamide clathrate;The dissolution of inclusion compounds was investigated. Results Compared with the glibenclamide bulk drug,butyl ether - β- cyclodextrin and Glibenclamide clathrate had increased the drug solubility significantly. Conclusion The preparation of butyl ether - β - cyclodextrin and glibenclamide clathrate had good practical application value.
Keywords：GlibenclamideButyl ether - β - cyclodextrinClathratePreparation method
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 401-403 )