The preliminary inquiry of nimesulide microcapsule suppository reduce Guinea pig liver toxicity
QU Hong-xuan
CHEN Xin-mei
XU Yi-ming
ZHAO Yuan
SUN Xiao-lei
Abstract：Objective To explore the influence of Nimesulide Microcapsule Suppository on reducing the liver toxicity of nimesulide. Methods Guinea pig were randomly divided into nimesulide ordinary suppository group and nimesulide mi-crocapsule suppository group. Each group respectively with rectal administration to use the corresponding suppository. After 15 days,Guinea pig were sacrificed and liver tissue ALT and AST activity observed path - ological changes in liver tis-sue. Results The nimesutide microcapsule suppository group of guinea pig was compared with the ordinary suppository group of guinea pig whose aspartate aminotransferase,alanine aminotransferase were significantly decreased,respectively (163. 159 1 ± 0. 748 6),(77. 525 1 ± 0. 679 4)U·L - 1 ,P < 0. 05;Microscopic observation of guinea pig liver biopsy,liver damage microcapsule suppository group of guinea pig was significantly lower extent. Conclusion Microcapsule suppository reduced liver toxicity nimesulide.
Keywords：NimesulideMicrocapsule suppositoryHepatotoxicity
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 379-380,393 )