Protective effect of 5F,an extract from Pteris semipinnata L,in combine with 5 - Fu,on development of lung cancer in A/J mice
YE Hua
LIU Yi
WU Ke-feng
LI Li
ZHENG Xue-bao
Abstract：Objective To investigate the effect of 5F,an extract from Pteris semipinnata L,in combine with 5 - Fu,on the model of induced A/ J mice lung cancer. Methods Intragastric administration was conducted on all mice using mixed re-vulsant of B[a]P and NNK. The aforementioned operation was performed once per week and continued for 8 weeks. 5F and 5- Fu,alone or in combination,were injected into mice from the ninth week and continued for 14 weeks. Count the number of lung cancer and calculate the tumor inhibition rate. Weight the liver and kidney,and calculate the organ index. The levels of ALT,AST,BUN,Scr,SOD and MDA were also detected. Results The combined application of 5F and 5 - Fu significantly suppressed the development of B[a]P and NNK - induced lung cancer in vivo with minimal side effects,and increase the level of serum SOD. Conclusion 5F combined with 5 - Fu had a synergistic effect on the induced lung cancer in A/ J mice.
Keywords：5FPteris semipinnata LLung cancerNNKB[a]P
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 373-375,386 )