Synthesis of ePlerenone
SHANG Yan-mei
ZHENG Zhong-hui
ZHAO Shu-juan
Abstract：With Δ9(11)-canrenone as raw material,eplerenone was obtained after a series of reaction process,inclu-ding sodium cyanide addition to give enamine( compound 4),hydrolysis to diketone( compound 3). After ring opening and eliminating in presence of sodium methoxide,diketone(compound 3)was converted to methyl ester(compound 2). Finally, epoxidation of compound 2 was performed by reaction with H2 O2 in the presence of trichloroacetamide or trichloroacetonitrile and K2 HPO4 ,giving eplerenone.
Keywords：Δ9(11)-canrenoneEplerenoneSynthesis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 365-367 )