Research Progress on Pharmacodynamic mechanism of Penta-O-galloyl-D-glucose for treating tyPe 2 diaBetes and comPlications
ZHANG Jian-bo
XIE Yu
YANG Hao-ran
FAN Yuan
Abstract：Penta-O -galloyl -D -glucose is a polyphenolic compound in many kinds of medicinal plants. Resent studies have shown that penta-O-galloyl-D-glucose can improve glucose tolerance and insulin-resistance,inhibit the activity of α-glucosidase and 11-β-HSD-1,inhibit the aggregation of IAPP and advanced glycation end products,imi-tate insulin,stimulate glucose transporter,improve diabetic nephropathy,diabetic neuropathy and diabetic angiopathy. Penta-O-galloyl-D-glucose exhibits the high value of treating type 2 diabetes and complications,penta-O-galloyl-D-glucose has some conditions to be the lead compound for treating diabetes.
Keywords：Penta-O-galloyl-D-glucoseType 2 diabetesPharmacodynamic mechanism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 344-348,352 )