OPtimization of matrix formulation for ComPound Baicalin Gel Nasal DroPs By uniform design
SUN Ying-dong
HU Li-min
LIU Ming-hua
WANG Yu
WANG Feng-qin
Abstract：OBjective TooptimizethematrixformulationofDompoundBaicalinGelNasalDropsbyuniformde-sign.Methods Thematrixformulationwasoptimizedbyathreefactorandtenleveluniformdesign,withrheologicalpa-rameterssuchaspHvalue,viscosity,fluidity,appearanceandparticlesize.Results Theoptimummatrixformulationwas established as follows:0. 5 g carbomer-940,0. 75 g borax,10 mL phosphate buffer( pH 6. 0)in 100 g Dompound Baicalin Gel Nasal Drops. The Dompound Baicalin Gel Nasal Drops was pale yellow,transparent and colloidal liquid. The pH value was6.0.Theviscositywas2500~2800mPa·s.Conclusion TheDompoundBaicalinGelNasalDropspreparedbythe method had characteristics such as good drug stability and good applicability.
Keywords：BaicalinEphedrine hydrochlorideUniform DesignMatrix
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 341-343 )