Study on determination of Clotrimazole Vaginal Tablets by HPLC
LI Na
YU Hong-yan
JIANG Ai-xia
Abstract：Objective To establish an HPLC method for the determination of Clotrimazole Vaginal Tablets. Methods Dalian C18 chromatographic column was adopted with methanol-phosphate buffer( phosphate from 5 mL and 50% methanol solution was diluted to 1 000 mL,with three procedures for adjusting the pH value to 3. 8)(40:60)as mobile phase,and the flow rate was 1. 0 mL·min-1 ,the detection wavelength was 230 nm,the injection volume was 10 μL. Results Under the chromatographic conditions,the linear range of clotrimazole was 0. 025~ 0. 2 mg·mL-1 ,the regression equation was A=30 397C-3. 353 83,r=0. 999 9. The RSD of repeatability test was 1. 35%,the average recovery rate was 96. 67%(RSD=1. 33%). Conclusion This method was sensitive,simple,accurate,reproducible,and can effectively control the content of Clotrimazole Vaginal Tablets.
Keywords：Clotrimazole Vaginal TabletsHPLC methodContent
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 280-281 )