Research progress on the molecular signaling pathway of castration-resistant prostate cancer
ZHANG Xiu-na
ZHAO Wei
GAO Xiao-fang
YANG Yong
JI Hui
Abstract：In United States,prostate cancer is the most commonly diagnosed non-cutaneous cancer in males and the second leading cause of cancer-related death for men. Androgen and the androgen receptor( AR)are critical effectors of prostate cancer. Consequently,androgen deprivation therapy( ADT)is typically employed as a first-line treatment for pros-tate cancer patients. While initial responses are generally positive,prostate tumors frequently recur and progress to a lethal form known as castration-resistant prostate cancer( CRPC). To study the relationship between androgen receptor and the initiation and development of CRPC,along with the possible molecular mechanisms,helps to diagnosis and treatment of cas-tration-resistant prostate cancer( CRPC),and provide the basis for further research.
Keywords：Castration-resistant prostate cancerAndrogen receptorSignal transductionMolecular mechanism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 225-228 )