Self-microemulsifying drug delivery system(SMEDDS)for a novel medicative compound against depression:physicochemical property and in vitro release
WU Lan
HE Wei
ZHAO Jin-hua
WANG Guo-cheng
YIN Li-fang
Abstract：Objective To study the physicochemical properties and in vitro release of a self-microemulsifying drug delivery system( SMEDDS)of AJS,the code name of an untitled novel medicative compound. Methods To study the rheo-logical properties and electrical properties of AJS-SMEDDS by examining its viscosity,zeta potential and particle size. The in vitro release of AJS-SMEDDS was examined by the bulk-equilibrium reverse dialysis bag technique. The stability of AJS-SMEDDS was also examined. Results AJS-SMEDDS was a plastic fluid with a zeta potential of -2. 76 mV and a particle size of(26. 08 ± 1. 68)nm. The quality of AJS-SMEDDS was stable during storing period in room temperature as well as low temperature. Conclusion AJS-SMEDDS was suitable for industrial production with a stable quality.
Keywords：Self-microemulsifying drug delivery system( SMEDDS)Particle sizeFluidStabilityDrug release
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 215-218 )