preParation and release characteristics of TebiPenem pivoxil Sustained - release Tablets
CHENG Jin-lai
CHEN Xiao-wei
DING BinG
Abstract：Objective To prepare Tebipenem Pivoxil Sustained — release Tablets and investigate the drug release mechanism in vitro. Methods HPMC K4M and HPMC K15M were used to prepare Tebipenem Pivoxil Sustained — release Tablets as matrix materials. Using the accumulative dissolution in vitro at different sampling time as the evaluation index,the formulation was optimized by the orthogonal design test. Results The optimal formulation had a remarkable sustained — re-lease property,the drug release profile in vitro followed first order kinetics,of which the mechanism was non — Fick diffu-sion. Conclusion The prepared tablets exhibited more ideal sustained — release characteristics in vitro.
Keywords：Tebipenem pivoxilSustained - release tabletsOrthogonal designDissolution
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 166-167,171 )