Preparation and quality inspection of Omeprazole Enteric-coated Pellets Capsules
LI Zheng-yuan
LI Hong-cheng
LI Feng-lin
SONG Cheng-gang
Abstract：objective To prepare omeprazole Enteric-coated Pellets Capsules. Methods Female pills of carried drug were directly prepared by centrifugal pill method,then pellets coating was adopted by fluidized bed coating method. The coating solution formulation was optimized by orthogonal design,to study the application of zein in isolation layer,and new enteric-coated prescription was used. Results The prepared omeprazole Enteric-coated Pellets had good stability,and good stability in acidic medium for 2 h. The acid strength≥98%,the release was up to the standard in buffer solution of pH 6. 8,and the vitro release for 45 min≥90%. Conclusion The method was simple and reduced costs. The stability of ome-prazole was raised with zein as the spacer layer forming material. Using glycerol monostearate in the enteric layer,not only promoted the release of the pellets in vitro,but also enhanced the stability of enteric coating.
Keywords：omeprazoleFemale drug pillsorthogonalZeinStabilityGlyceryl monostearate
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 91-94,99 )