The genetic factors of imPacting irinotecan efficacy and adverse reactions
ZHAO Renyong
ZHANG Rui
GUO Ruichen
Abstract：Irinotecan is a semisynthetic derivant of camptothecin,is widely used for chemotherapy of a variety of tumors. The pharmacokinetics of irinotecan is extremely complex and the individual variation is significant. Irinotecan′s me-tabolism is affected by various polymorphic enzymes and drug transporters,including carboxylesterases,uridine diphosphate glucuronosyltransferase,cytochrome P450 3A,β—glucuronidase,pregnane X receptor and the adenosine—triphosphate de-pendencing transporters. In this article,these factors and the gene polymorphism were reviewed.
Keywords：IrinotecanPolymorphismEnzymesTransporter
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 33-37 )