FormuIa and PreParation method of best 10% Potassium ChIoride PraI SoIution by orthogonaI exPeriment
ZHANG Haixia
FENG Rui
HU Limin
sUN shaowei
MA Jing
WANG Yu
Abstract：Pbjective To optimize the formula and preparation method of best 10% Potassium Chloride Oral Solution by orthogonal experiment. Methods The orthogonal experiment was used. The dosage of 5% hydroxy ethyl benzene solu-tion( mL),water temperature(℃)and dissolving water quantity( mL)were experimental factors. Adopting 5 levels together composed the orthogonal experiment of three actors and five levels arranged according to standard orthogonal table L25(53 ). The appearance of 10% potassium chloride oral solution and the composite score of microbial limit were indexes. ResuIts The best formula was potassium chloride 100 g,5% hydroxy ethyl benzene solution 6~7 mL and normal temperature puri-fied water add to 1 000 mL. The best preparation method was purified water 600 mL of 60 ℃ dissolving the potassium chlo-ride,slowly adding 5% hydroxy ethyl benzene solution 6~7 mL in the condition of stirring,till evenly,finally joining the normal temperature purified water. ConcIusion The property of best 10% potassium chloride oral solution by orthogonal experiment was stable. The preparation method was simple and easy.
Keywords：10Potassium Chloride Oral SolutionPreparation methodOrthogonal experiment
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 26-28 )