Synthesis of fingolimod
LIU Jian-feng
SU Peng
HAN Jian-kui
HOU Gui-hua
XU Wen-fang
LI Yue-kai
Abstract：Objective To synthesize fingolimod. Methods Fingolimod was synthesized with 2-phenethyl alcohol and sodium bromide as starting material,and through a series of reactions,such as substitution,acylation,condensation etc. Results The struture of target compound was confirmed by 1 H-NMR and MS. The overall yield of the process was 26. 9 % . Compared with the reported method,the overall yield was 6. 4% higher. Conclusion This synthetic process was convenient,and had high yield,low cost,and mild reaction condition. It was suitable for industrial production by its opera-tion,low cost and.
Keywords：2-phenethyl alcoholSodium bromideFingolimodImmunosuppressant
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 739-741 )