The effects of budesonide combined with small dose of azithromycin on tidal breathing lung function of children with small airways damaged after bronchiolitis

ZHANG Jing

Abstract：Objective The children with bronchiolitis in acute infection after inflammatory changes in the small air-ways damaged. High resolution CT examination and tidal breathing pulmonary function test are often used in children with moisture assessment prognosis. In this paper,the efficacies were approached by comparing effects of simply nebulized budes-onide and budesonide combined with small dose of azithromycin on children's lung function,and to compare the efficacies of two treatment protocols with or without differences. Methods 25 cases of patients with bronchiolitis,divided into the exper-imental group 13 cases,remained to give atomization inhalation of budesonide and low dose oral azithromycin in treatment for 3 months after the asthmatic symptoms disappeared. 12 cases as the control group were only given budesonide for 3 months. Pulmonary function and high resolution CT examination of two groups were examined before treatment,and when treating a month,three months. The effects of two therapeutic schemes were analyzed. Results and Conclusion In 25 pa-tients,comparing the tidal breathing lung function in pretherapy and convalescent,the differences of VT/Kg,Ti,Te,Ti/Te, TPTEF/TE,VPTEF/VE had statistical significance,and treating a months and three months had no statistical significance. Two groups of children after treating one and three months carried out high resolution CT examination,the majority of chil-dren were improved in different degree. The experimental group and the control group children with different treatment after 1 and 3 months of tidal pulmonary function in VT,TPTEF/TE,VPTEF/VE had no statistical significance.