Preparation of Atorvastatin Calcium Fast-release Pellets by extrusion-spheronization
LIU Jia-sheng
GUO Yu
Abstract：Objective To prepare Atorvastatin Calcium Fast-release Pellets by extrusion-spheronization and study the influence of formulation and process parameters on the properties of the pellets. Methods Using single factor test,for-mulation and preparation technology of the pellets were optimized. Effects of the key parameters on the properties of the pel-lets,yield and dissolution were investigated using orthogonal design. Results Atorvastatin Calcium Fast-release Pellets presented perfect sphericity and high yield with sharp size distribution. More than 95% of the drugs were released from the pellets in 30 min. Conclusion Atorvastatin Calcium Fast-release Pellets were successfully prepared by extrusion-spher-onization with good reproducibility and high-quality,and had a remarkable fast-release property in vitro.
Keywords：Extrusion-spheronizationAtorvastatin calciumFast-release pelletsOrthogonal design
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 705-706,723 )