Study oN tHe preparatioN aNd stability of Isosorbide MoNoNitrate SustaiNed-release Tablets
YAN Xie-guo
TAO An-jin
Abstract：Objective To prepare Isosorbide Mononitrate Sustained-release Tablets,and to investigate the stability of the tablets. MetHods The formulation of sustained-release tablets of isosorbide mononitrate was optimized by uniform de-sign,and hydroxypropyl methycellulose( HPMC)as matrix material. The release profile was compared with that of Im-dur. The stability of tablets was studied under conditions of(40 ± 2)℃ and relative humidity 75% ± 5% exposure. Results The samples had the similar sustained-release property with that of Imdur. The tablets were stable to the temperature and relative humidity conditions of(40 ± 2)℃ and 75% ± 5% for 6 months. CoNclusioN Preparation process of Isosor-bide Mononitrate Sustained-release Tablets was simple and the quality can be controlled,which met the requirement for large scale production.
Keywords：Isosorbide mononitrateSustained-release tabletsStability
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 651-653,660 )