PreparatioN of HuoxuetoNgmai Soft Capsules aNd its dissolutioN iNvestigatioN
KONG Ling-ti
DAI Long
Abstract：Objective To prepare Huoxuetongmai Soft Capsules with wet ultrafine grinding technology,and evaluate its dissolution. MetHods Using particle size and material stability as evaluation indexes,different dispersion medium,medium dosage,grinding time and grinding temperature were studied by single factor method. The dissolution of soft capsules was comparing with commercially capsules using polypeptide content as indicator. Results The optimal process was:PEG400, which containing 8% propylene glycol,was added to the power of whitmania pigra at the ratio of 3. 8:1,and then ultrafine grinding under 40 ℃ for 30 min. The dissolution rate in 60 min of soft capsules and commercially capsule was 75. 74% and 29. 57%,respectively. CoNclusioN The dissolution of soft capsules was significantly higher than commercially available capsules,suggesting that it had better bioavailability and broad application prospects.
Keywords：Huoxuetongmai Soft CapsulesWet ultrafine grindingWhitmania pigraDissolution
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 647-650 )