DetermiNatioN of glyceriN iN CetiriziNe HydrocHloride LiNimeNt by HPLC-RID
SHAO Jie
SUN Jian-he
HAN Zhong-li
Abstract：Objective To establish an HPLC-RID method for the determination of glycerin in Cetirizine Hydrochlo-ride Liniment. MetHods Welch Xtimate NH2 column(4. 6 mm × 250 mm,5 μm)was adopted with the mobile phase of acetonitrile-water(75:25),the column temperature was 30 ℃,the flow rate was 1. 0 mL·min-1 and the RID temperature was 35℃. Results The linear range was 1. 006 4~5. 032 mg·mL-1 ,the regression coefficient was 0. 999 3. The average recovery was 102. 7%,and the RSD was 1. 8%( n=6 ). CoNclusioN The method was specific,accurate,convenient and quick.
Keywords：Cetirizine Hydrochloride LinimentGlycerinHPLC-refractive index
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 640-641,644 )